Protective effect of Polygonatum sibiricum Polysaccharide on D-galactose-induced aging rats model.
Identifieur interne : 000079 ( Main/Exploration ); précédent : 000078; suivant : 000080Protective effect of Polygonatum sibiricum Polysaccharide on D-galactose-induced aging rats model.
Auteurs : Shaoyan Zheng [Oman]Source :
- Scientific reports [ 2045-2322 ] ; 2020.
Descripteurs français
- KwdFr :
- Agents protecteurs (pharmacologie), Animaux (MeSH), Calcium (métabolisme), Composés phytochimiques (pharmacologie), Facteurs de croissance fibroblastique (métabolisme), Galactose (effets indésirables), Glucuronidase (métabolisme), Hydrates de carbone alimentaires (effets indésirables), Mâle (MeSH), Phosphore (métabolisme), Polygonatum (composition chimique), Polyosides (pharmacologie), Rat Sprague-Dawley (MeSH), Rats (MeSH), Stress oxydatif (effets des médicaments et des substances chimiques), Vieillissement (effets des médicaments et des substances chimiques).
- MESH :
- composition chimique : Polygonatum.
- effets des médicaments et des substances chimiques : Stress oxydatif, Vieillissement.
- effets indésirables : Galactose, Hydrates de carbone alimentaires.
- métabolisme : Calcium, Facteurs de croissance fibroblastique, Glucuronidase, Phosphore.
- pharmacologie : Agents protecteurs, Composés phytochimiques, Polyosides.
- Animaux, Mâle, Rat Sprague-Dawley, Rats.
English descriptors
- KwdEn :
- Aging (drug effects), Animals (MeSH), Calcium (metabolism), Dietary Carbohydrates (adverse effects), Fibroblast Growth Factors (metabolism), Galactose (adverse effects), Glucuronidase (metabolism), Male (MeSH), Oxidative Stress (drug effects), Phosphorus (metabolism), Phytochemicals (pharmacology), Polygonatum (chemistry), Polysaccharides (pharmacology), Protective Agents (pharmacology), Rats (MeSH), Rats, Sprague-Dawley (MeSH).
- MESH :
- chemical , adverse effects : Dietary Carbohydrates, Galactose.
- chemical , metabolism : Calcium, Fibroblast Growth Factors, Glucuronidase, Phosphorus.
- chemistry : Polygonatum.
- drug effects : Aging, Oxidative Stress.
- chemical , pharmacology : Phytochemicals, Polysaccharides, Protective Agents.
- Animals, Male, Rats, Rats, Sprague-Dawley.
Abstract
The polysaccharide of Polygonatum sibiricum (PSP)is one of the main active ingredients of Polygonatum Polygonatum in Liliaceae. It has anti-tumor, anti-aging, immune regulation, and anti-oxidative effects. Recent studies have shown that the Klotho gene and fibroblast growth factor-23 (FGF-23) have a common receptor, which is closely related to aging and highly expressed in kidney and meninges. Our study aimed to investigate the anti-aging effect of PSP on D-galactose-induced rats and its mechanism. D-galactose (120 mg Kg-1) and PSP (100 mg Kg-1) was used to intervene in rats, respectively. Then The changes of indexes of the natural aging-like model rats before and after PSP intervention were observed. We found that PSP could significantly improve the learning and memory abilities of rats and reverse the pathological changes of kidney tissues in rats. At the same time, PSP up-regulated the expression of Klotho mRNA and Klotho protein in the renal cortex, down-regulated the expression of FOXO3a mRNA and p-FOXO3a protein in renal tissue, and inhibited the expression of FGF-23 protein in the femur. Our studies suggest that PSP may play a role by regulating the Klotho-FGF23 endocrine axis, alleviating oxidative stress, and balancing calcium and phosphorus metabolism.
DOI: 10.1038/s41598-020-59055-7
PubMed: 32042011
PubMed Central: PMC7010663
Affiliations:
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It has anti-tumor, anti-aging, immune regulation, and anti-oxidative effects. Recent studies have shown that the Klotho gene and fibroblast growth factor-23 (FGF-23) have a common receptor, which is closely related to aging and highly expressed in kidney and meninges. Our study aimed to investigate the anti-aging effect of PSP on D-galactose-induced rats and its mechanism. D-galactose (120 mg Kg<sup>-1</sup>) and PSP (100 mg Kg<sup>-1</sup>) was used to intervene in rats, respectively. Then The changes of indexes of the natural aging-like model rats before and after PSP intervention were observed. We found that PSP could significantly improve the learning and memory abilities of rats and reverse the pathological changes of kidney tissues in rats. At the same time, PSP up-regulated the expression of Klotho mRNA and Klotho protein in the renal cortex, down-regulated the expression of FOXO3a mRNA and p-FOXO3a protein in renal tissue, and inhibited the expression of FGF-23 protein in the femur. Our studies suggest that PSP may play a role by regulating the Klotho-FGF23 endocrine axis, alleviating oxidative stress, and balancing calcium and phosphorus metabolism.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32042011</PMID><DateCompleted><Year>2020</Year><Month>11</Month><Day>11</Day></DateCompleted><DateRevised><Year>2020</Year><Month>11</Month><Day>11</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2045-2322</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>02</Month><Day>10</Day></PubDate></JournalIssue><Title>Scientific reports</Title><ISOAbbreviation>Sci Rep</ISOAbbreviation></Journal><ArticleTitle>Protective effect of Polygonatum sibiricum Polysaccharide on D-galactose-induced aging rats model.</ArticleTitle><Pagination><MedlinePgn>2246</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41598-020-59055-7</ELocationID><Abstract><AbstractText>The polysaccharide of Polygonatum sibiricum (PSP)is one of the main active ingredients of Polygonatum Polygonatum in Liliaceae. It has anti-tumor, anti-aging, immune regulation, and anti-oxidative effects. Recent studies have shown that the Klotho gene and fibroblast growth factor-23 (FGF-23) have a common receptor, which is closely related to aging and highly expressed in kidney and meninges. Our study aimed to investigate the anti-aging effect of PSP on D-galactose-induced rats and its mechanism. D-galactose (120 mg Kg<sup>-1</sup>) and PSP (100 mg Kg<sup>-1</sup>) was used to intervene in rats, respectively. Then The changes of indexes of the natural aging-like model rats before and after PSP intervention were observed. We found that PSP could significantly improve the learning and memory abilities of rats and reverse the pathological changes of kidney tissues in rats. At the same time, PSP up-regulated the expression of Klotho mRNA and Klotho protein in the renal cortex, down-regulated the expression of FOXO3a mRNA and p-FOXO3a protein in renal tissue, and inhibited the expression of FGF-23 protein in the femur. Our studies suggest that PSP may play a role by regulating the Klotho-FGF23 endocrine axis, alleviating oxidative stress, and balancing calcium and phosphorus metabolism.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Shaoyan</ForeName><Initials>S</Initials><Identifier Source="ORCID">0000-0001-7996-589X</Identifier><AffiliationInfo><Affiliation>Pharmacy Department, Foshan Women And Children Hospital Affiliated to Southern Medical University, Foshan, P.R. 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